Chloroquine in lactation

Discussion in 'Plaquenil Generic' started by Quqush, 18-Mar-2020.

  1. 98a Well-Known Member

    Chloroquine in lactation


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Eleven women were given 600 mg of chloroquine base orally. The peak chloroquine plus desethylchloroquine in milk averaging 4.4 mg/L occurred an average of 14.4 hours after the dose. Chloroquine and desethylchloroquine were detected in the urine of the 4 infants who were tested. Breastfeeding. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Drug Interactions. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Lactation. Because of the potential for serious adverse reactions in nursing infants from chloroquine, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account potential clinical benefit of drug to mother. Pregnancy Categories. A Generally acceptable.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine in lactation

    Safety in Lactation Antimalarials – SPS - Specialist., Hydroxychloroquine Oral Route Before Using - Mayo Clinic

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  4. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat.

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    Chloroquine Levels and Effects while Breastfeeding Summary of Use during Lactation Very small amounts of chloroquine are excreted in breast milk; when given once weekly, the amount of drug is not sufficient to harm the infant nor is the quantity sufficient to protect the child from malaria. Chloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria and to prevent malaria in areas or regions where chloroquine is known not to work resistance. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Hydroxychloroquine is rapidly absorbed from the gastrointestinal tract, and steady-state concentrations are reached after 4–6 weeks; 45% of hydroxychloroquine binds to plasma proteins that are deposited in tissues such as the liver.

     
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