Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and liver problems What does hydroxychloroquine combined with methotrexate do for ra Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil knee side effects Long-Term Side Effects of Plaquenil for Rheumatoid., Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Desethyl hydroxychloroquine Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Plaquenil Side Effects - GoodRx. Plaquenil Side Effects on Your Eyes and Vision. Hydroxychloroquine Side Effects -. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. But you can’t even compare it to the only other things I have to treat lupus—prednisone, where 100 percent of people get side effects, or immunosuppressive drugs, which suppress the immune system, potentially causing infections, low blood counts, and liver toxicity. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.