Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil palindromic rheumatism Plaquenil and tylenol cold and flu severe Daily dose greater than 400 mg or, in people of short stature, a daily dosage over 6.5 mg/kg ideal body weight or total cumulative dose of more than 1,000 g ; medication use longer than five years ; concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. A cumulative dose of 1000g HCQ is reached in 7 years with a typical daily dose of 400 mg. In the same study, toxicity was not related to age, weight or daily dose but was related to duration of use and increased rapidly after 5 to 7 years; thus, it is important to be aware of the risk factors and use more effective protocols of screening on all the patients who exceed 5 years of exposure. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil toxicity cumulative dose Plaquenil Dosage Guide -, Recommendations on Screening for Chloroquine and. Can you combine doxycycline hyclate with plaquenilChloroquine lymeHow good is plaquenil for diabetes Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age. Hydroxychloroquine toxicity - EyeWiki. Retinal toxicity associated with chronic exposure to.. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Usual Adult Dose for Malaria Prophylaxis. Suppression 400 mg 310 mg base orally on the same day every week Comments-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg 620 mg base may be taken in 2 divided doses 6 hours apart. The Hydroxychloroquine Dosing Calculator calculates appropriate daily dose of hydroxychloroquine. Calc Function ; Calcs that help predict probability of a disease Diagnosis. Subcategory of 'Diagnosis' designed to be very sensitive Rule Out. Disease is diagnosed prognosticate to guide treatment Prognosis.