Less than 50% of pregnancies in women with lupus have complications, but all lupus pregnancies are considered high-risk. Lupus can complicate pregnancy with an increased risk of miscarriage, premature delivery, and preeclampsia, as well as heart problems in the baby. Plaquenil and neurontin How bad is plaquenil on organs Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Primaquine is contraindicated in pregnancy due to the risk of severe haemolysis in glucose-6-phosphate dehydrogenase G6PD deficient individuals. Pregnant women may require suppressive treatment, usually with chloroquine, until delivery. Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. “Preconception counseling allows women who have lupus to discuss their personal health with their doctor to assess risks based on how lupus has affected her thus far,” says Larry Matsumoto, MD, maternal fetal specialist at Atlanta Perinatal Consultants. If you have lupus and are considering having a baby, consider these tips to ensure a safe pregnancy and healthy baby. Chloroquine during pregnancy Lupus and Pregnancy Tips for Living with Lupus While Pregnant, Management of malaria in pregnancy Plaquenil kidney damageHydroxychloroquine and chloroquine retinopathyChloroquine intercalatingChloroquine ich treatment loachesChloroquine mechanism of action iodine Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. This drug should only be used during pregnancy if the potential benefit justifies the potential risk. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Use During Pregnancy. Hydroxychloroquine MotherToBaby. Background/Purpose Chloroquine CQ and Hydroxychloroquine HCQ have been used for years during pregnancy for multiple indications malaria prevention, autoimmune disorders, etc. Recently, some countries face restrictions to prescribe these drugs during pregnancy, due to report of ocular toxicity in animal models and potential genotoxicity. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus. REFERENCES. 1. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus.