Hydroxychloroquine qt prolongation

Discussion in 'North West Pharmacy Canada' started by ovor2003, 03-Mar-2020.

  1. deyatelnost Well-Known Member

    Hydroxychloroquine qt prolongation


    The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened.

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    HS34-HS40. ABSTRACT QT prolongation is a rare adverse event associated with many drugs, including antipsychotics and antidepressants. The majority of cases have occurred in patients taking an offending agent with multiple identifiable risk factors for corrected QT QTc prolongation. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Ventricular arrhythmias and torsade de pointes have been reported with the use of hydroxychloroquine. QT prolongation has occurred during therapeutic use of atomoxetine and following overdose. Long QT Syndrome LQTS Figure demonstrating an EKG with prolonged QT interval The QT interval represents ventricular depolarization and repolarization. The QT interval varies with heart rate. The faster the heart rate the shorter the QT interval. The corrected QT QTc interval is calculated by dividing the measured QT in seconds by.

    The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used.

    Hydroxychloroquine qt prolongation

    Life Threatening Severe QTc Prolongation in Patient with., Plaquenil hydroxychloroquine sulfate dose, indications.

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  7. Hydroxychloroquine HCQ is used for treatment of lupus erythematosus. The cardiac toxicity of HCQ has focused primarily on acute intoxication. We report a case of chronic use of HCQ associated with torsade de pointes. Case report. A 67-year-old female presented with acquired long QT interval syndrome with a refractory ventricular arrhythmia.

    • Chronic Hydroxychloroquine Use Associated with QT..
    • Long QT Syndrome LQTS.
    • Drugs and the QT Interval – What Do Pharmacists Need to Know?.

    Plaquenil® hydroxychloroquine sulfate is a white or practically white, crystalline powder, freely soluble in water; practically insoluble in alcohol, chloroform, and in ether. The chemical name for hydroxychloroquine sulfate is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Hydoxychloroquine HCQ is widely used for the treatment of rheumatoid arthritis RA and systemic lupus erythematosus SLE with a side-effect profile including myopathy and cardiotoxicity. Acute HCQ poisoning has been reported to cause a prolonged QT interval, hypokalaemia and a prolonged QRS complex.

     
  8. Musatov Well-Known Member

    Oral route (Capsule, Extended Release) Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Medications and Drugs That May Hurt Your Eyes. Plaquenil Hydroxychloroquine Sulfate - Sanofi RA and Your Eyes Complications Rheumatoid Arthritis.
     
  9. Ciel Moderator

    13 mg/kg (10 mg/kg base), not to exceed 800 mg (620 mg base) followed by 6.5 mg/kg (5 mg/kg base), not to exceed 400 mg (310 mg base), at 6 hours, 24 hours and 48 hours after the initial dose. Advanced Multifocal ERG mfERG Diopsys Common and Rare Side Effects for Plaquenil Oral Treating Lupus with Anti-Malarial Drugs Johns Hopkins.
     
  10. Baulder Moderator

    Taking Plaquenil for Rheumatoid Arthritis Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses