Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil side effects right away Anti malarial medication hydroxychloroquine Asians and plaquenil toxicity Jan 15, 2020 Plaquenil and Skin hyperpigmentation - a real-world study. Summary Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram. Oct 01, 2012 However, most reports have described chloroquine‐induced hyperpigmentation, and hyperpigmentation due to hydroxychloroquine has been rarely reported. We herein report a case of hydroxychloroquine‐induced hyperpigmentation. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine hyperpigmentation Hydroxychloroquine-induced Hyperpigmentation of the Skin., Hydroxychloroquine‐induced hyperpigmentation, The Journal of. What to expect when taking plaquenil for the first timeWhat happens if you take too much hydroxychloroquine Improvement of the hyperpigmentation a few months after hydroxychloroquine is stopped has been reported, but complete clearance is rare.1 Cautious use of the Q-switched ruby laser has shown promise in the treatment of nonmelanotic hyperpigmentation in limited case reports.5 Our patient’s skin discoloration partially resolved four months after switching to chloroquine. Hydroxychloroquine-related skin discoloration CMAJ. Systemic Scleroderma Skin Involvement Hyperpigmentation and.. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Oct 30, 2008 Rare, previous reports of hyperpigmentation indicate the presence of both melanin and hemosiderin in patients being treated with antimalarial medication. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to melanin. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.