Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Plaquenil bone pain Hydroxy chloroquine 200 mg Plaquenil overdose amount I have been reading up on stress and what that can cause and do to a person. My body feels so much better, what do you make of this? Thank you, Loretta. Answer. There is no problem with stopping methotrexate abruptly, with the exception that you might flare if you indeed have active ongoing RA. Talk to your rheumatologist I have missed 2 days of my Plaquenil- I have questions! Support Forums. I am no doctor, but my rhuemy did say you cannot quit cold turkey, its a weaning process. So what I'm trying to say, is that from my experience, not from my doctor's point of view, YES skipping plaquenil will make you feel different possible hurt or swell more. When to Call 911. If you or someone you know is showing signs of a heart attack or seizure while quitting cold turkey, call 911 immediately. Symptoms of a heart attack may include Shortness of breath. Chest pain. Pain or discomfort in the jaw, neck or back. Weakness, lightheadedness or faintness. Did you take yourself off Plaquenil, or did your doctor tell you to go off it? Plus I will be honest the whole eye site thing even though rare has always freaked me out. I went off of it to see if I can manage not being on it as my lupus isnt as severe as other cases but already I am feeling very fatigued and my legs feel heavy if that makes sense. I can discuss alternatives with my DR at my next appt but my DR feels as though the plaq is the best bet for my level of illness. If so are you just dealing with Lupus symptoms or did you take another med? I'm on Plaquenil, and after the first week's GI upset, I have had no problems with it. What could happen if you cold turkey plaquenil Stopping Plaquenil - General Discussion - Life With Lupus, I have missed 2 days of my Plaquenil- I have questions! Does plaquenil reduce spleen inflammationPlaquenil and ibuprofen interactionChloroquine phosphate in pregnancyHydroxychloroquine interactionsHydroxychloroquine and doxycycline Jul 20, 2017 What can happen during withdrawal. Alcohol is a depressant, meaning it slows or lowers the functioning of the central nervous system. Through chronic usage, the body eventually becomes conditioned to the presence of alcohol and is able to adapt to it. Alcohol Withdrawal Cold Turkey Dangers. What Are the Risks of Quitting Cold Turkey?. Stopping plaquenil. DailyStrength. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. With the condition your in already by the sounds of it I wouldnt mess with it. why dont you just kinda fake it? the damage wouldnt be worth the cash. personally all I take is minocycline but if I was in your shoes I wouldnt stop if it provided a certain level of releif. and yes plaquenil does lose its affectiveness if you stop taking it. my moms cousin took it for years as it gave him the. Plaquenil was supressing the RA, so when you went off it the RA was free to manifest itself once more. Plaquenil is an antimicrobe, not an immunsuppressant, so you should be able to use it even if you're prone to infection. That said, because you are prone to infection and you don't have a lot of oprions, you sound like you would really benefit from antibiotic protocol therapy, since it involves no immunesuppressants at all.