Chloroquine phosphate pharmacokinetics

Discussion in 'Generic Chloroquine' started by pendolf, 08-Mar-2020.

  1. FutureXX User

    Chloroquine phosphate pharmacokinetics


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. The relationship of the pharmacokinetics of chloroquine to dose in the rabbit. Aderounmu AF, Lindstrom B, Ekman L. Four albino rabbits were treated with 4 different doses of chloroquine phosphate 30-50 mg kg-1 given intragastrically and 10 others were given the hydrochloride 2.5-12.5 mg kg-1 i.v. Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally. Severe malnutrition such as kwashiorkor effects absorption but diahrrea does not. Both HCQ and CQ have prolonged half-lives, between 40 and 50 days, and low blood clearance e.g. hydroxychloroquine's blood clearance is 96 ml/min.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine phosphate pharmacokinetics

    Pharmacokinetics of Chloroquine and Metronidazole in Rats, The relationship of the pharmacokinetics of chloroquine to.

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  6. Pharmacokinetics and bioavailability of chloroquine The median concentration-time profiles of chloroquine in the three groups were similar Figure 5. No significant differences were found between the three groups for any of the pharmacokinetic parameters Table 3.

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    Mg 250 mg of chloroquine phosphate daily. a When used in conjunction with topical corticosteroids in treatment of discoid lupus erythematosus, skin lesions may regress within 3–4 weeks and new lesions may not appear. a When systemic and cutaneous manifestations of lupus erythematosus subside. Dose for Chloroquine phosphate This dose is recommended in malaria and it should be given at the same day of each week. Paedriatic Dosage 20kg 3 mg/kg 3 3 The following interactions have been observed on treatment with the structurally related substance chloroquine phosphate, and therefore cannot be ruled out for hydroxychloroquine. Praziquantel. Chloroquine has been reported to reduce the bioavailability of praziquantel. Antacids and kaolin

     
  7. SAN Well-Known Member

    Also known as: Plaquenil, Quineprox The following information is NOT intended to endorse any particular medication. Drugs That Slow RA's Progress DMARDs, Biologics, and More RA Medications What are Disease Modifying Antirheumatic. Taking Plaquenil for Rheumatoid Arthritis
     
  8. akdeniz Well-Known Member

    PLAQUENIL Side Effects, Reviews by Patients - Yay! Dr stopped Hydroxychloroquine plaquenil yesterday fearing it is now doing more harm than good. Over all I do feel it may have caused increased anxiety and depression and irritability.however lupus alone can trigger those symptoms I'm sure. Overall Plaquenil did take away the muscle and joint pain. It worked wonders for that.

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  9. nikoola Moderator

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

    Plaquenil rationing - Lupus - Inspire