Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil ulcerative colitis Plaquenil how does it work Importance Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Objective To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. I've been on Plaquenil 400mg a day for almost 4 years. I haven't noticed any skin discoloration but my hair turned grey at a very young age and I've always kept it natural, but as of late it is turning yellowish and my hair dresser thinks it is from the medication. Skin discoloration - bluish in Plaquenil - how severe and when it was recovered? Summary We study how severe was Skin discoloration - bluish, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil skin discoloration Skin Pigmentation with Hydroxychloroquine, Plaquenil and skin discoloration - Sjogren's World Drug interaction domperidone chloroquine She presented 3 months later with multiple skin lesions predominantly on her neck, bilateral forearms, and dorsal feet. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Skin discoloration - bluish in Plaquenil how severe and.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Rheumatoid arthritis RA mainly affects the joints. But it, and many of the medications that treat it, can also affect the you recognize any of these problems? Rheumatoid Nodules. About 1. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. For people with skin problems This drug may.