Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Toxicity of hydroxychloroquine Would chloroquine in a sickle cell patient beh harfmul Effects of plaquenil on skin I'm glad to read you're doing well on the Plaquenil but I have to ask why you're doing a taper down. If your doctor is telling you to do this, what's the reason? If you don't have to make a change, I dont think I'd mess with the dosage. I'd hate for your symptoms get worse. One of the most ill advised things I did was go off Plaquenil for a few. Plaquenil damps down the reactiveness of the receptors that send out your “fighters”, which in us is overactive. Rather than strangling the life out of your immune system like steroid meds do, it attenuates the function to closer to normal. Over time it can slightly lower your white cell count. Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower. Did you take yourself off Plaquenil, or did your doctor tell you to go off it? Plus I will be honest the whole eye site thing even though rare has always freaked me out. I went off of it to see if I can manage not being on it as my lupus isnt as severe as other cases but already I am feeling very fatigued and my legs feel heavy if that makes sense. I can discuss alternatives with my DR at my next appt but my DR feels as though the plaq is the best bet for my level of illness. If so are you just dealing with Lupus symptoms or did you take another med? I'm on Plaquenil, and after the first week's GI upset, I have had no problems with it. How to taper off plaquenil Is it common practice to wean off plaquenil., Stopping Plaquenil - General Discussion - Life With Lupus Hydroxychloroquine and drinking alcohol In past decades, a diagnosis of rheumatoid arthritis often signified a long-term struggle to control the disease and improve quality of life. However, in more recent years, significant advances in. Drug tapering An option, not a necessity, for patients.. Prednisone and Plaquenil question" Lupus Community - Support Group. Let me tell you what weaning down from Plaquenil is like.. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. I have been taking Plaquenil 400 mg per day for about 2 years now due to lupus flare. When i first started it, I was also started on prednisone to get my inflammation under control. Actually I started on 200 mg per day and about 2 months before tapering off pred, he upped me to 400 mg per day of plaquenil to give it plenty of time to kick in. I think tapering off over a month or so would be fine, but I would NOT go cold turkey on this one. Maybe your doc will want to switch you to another SNRI like Effexor to help during the taper off. And of course you can’t really cut the tabs in half due to the time-release coating.