Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and breastfeeding Plaquenil copay cards Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other. In 1956, the U. S. Food and Drug Administration approved HCQ for symptoms of lupus and rheumatoid arthritis, particularly skin inflammation, hair loss, mouth sores, fatigue, and joint pain. Dosing. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine dose for lupus CHLOROQUINE Drug BNF content published by NICE, Drug spotlight on hydroxychloroquine Lupus Foundation of. Plaquenil cardiomyopathy mriChloroquine does not inhibit dna synthesisPlaquenil tylenol interaction Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. How is plaquenil hydroxychloroquine used to treat lupus?. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Chloroquine vs Hydroxychloroquine Comparison -. Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. Hydroxychloroquine dosing information. Usual Adult Dose for Malaria Treatment of the acute attack 800 mg 620 mg base followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial dosage.