Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. How effective is plaquenil How to dissolve chloroquine The study is based on hydroxychloroquine sulfate and methotrexate sodium the active ingredients of Plaquenil and Methotrexate, respectively. Other drugs that have the same active ingredients e.g. generic drugs or brand names are also considered. Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Jun 09, 2006 Hochberg MC, Tracy JK, Hawkins-Holt M, Flores RH 2003 Comparison of the efficacy of the tumour necrosis factor α blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis. Ann Rheum Dis 62Suppl 2ii13–ii16 PMC free article Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate or plaquenil Methotrexate and plaquenil - @Kristinsaba1988., Methotrexate vs Plaquenil? - A patient will begin taking hydroxychloroquine for rheumatoid arthritis Jul 18, 2014 Cardiovascular risk evaluation. Prior to elective surgery, the risk of perioperative cardiovascular events must be assessed. Overall, individuals with rheumatoid arthritis have a higher risk of myocardial infarction which is similar to individuals with diabetes mellitus or a person 10 years older than the age of the patient. Perioperative management of the patient with rheumatoid arthritis. Perioperative Management of Medications Used in the Treatment.. Effects of methotrexate and hydroxychloroquine combination.. With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks I told my doctor I wanted to research a bit before I gave an answer. Do you think I should try the Plaquenil first before starting MTX or is it fine to jump to MTX? From what I read so far, seems like methotrexate is a bigger drug with more side effects so plaquenil would be the better choice. Any information would be helpful.