Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. How does plaquenil work for rheumatoid arthritis Hydroxychloroquine decrease inflammation Hydroxychloroquine sulphate Is plaquenil discontinued Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina. Plaquenil or hydroxychloroquine is under the quinolone family. These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine overdose side effects Plaquenil Overdose - Antibiotics Home Page, Hydroxychloroquine toxicity - EyeWiki Is plaquenil a mitochondrial toxin Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Accidental hydroxychloroquine overdose resulting in.. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Common side effects include headache; dizziness; loss of appetite; nausea; diarrhea; stomach pain; vomiting; nervousness; rash; Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects Plaquenil. For more information, ask your doctor or pharmacist. Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss.