Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and magnesium Stopping plaquenil lupus Does plaquenil treat lyme disease Aug 14, 2017 Neurological Disorders. According to the Mayo Clinic and New Zealand Dermatological Society, Plaquenil, given long term for diseases such as RA, can cause brain and nerve diseases such as headaches, dizziness, muscle weakness and seizures. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin. Loss of appetite. Abdominal bloating. Upset stomach. Nov 11, 2008 At mentions that in overdose conditions or hypersensitive patients, plaquenil can cause dizziness and heart palpitations -- so these are definitely issues that you should talk to your doctor about. Perhaps there is a dosage between 200 and 400 that will be right for you. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Dizziness and plaquenil Common and Rare Side Effects for Plaquenil Oral, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Chloroquine diphosphate and phosphate For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Study Raises Questions about Sjogren's and Plaquenil. Increasing plaquenil, having problems. Plaquenil Indications, Side Effects, Warnings -. Dizziness is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have Osteoporosis. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. Lupus Flare – signs and symptoms Aching or increased swelling of the joints. Weakness and pain of the muscles. Unusual fevers. Unusual exhaustion and/or fatigue. Hair loss. Dizziness and difficulty with focus and memory. Digestive Problems. Two days later the rash spread to my chest, stomach, and back. Went to urgent care where I was told it was most likely a reaction to the Plaquenil. Received a cortisone shot and a prescription for Prednisolone six day pack, and an antihistamine.